Research News

Video showing NK-92/5.28.z, ErbB2-CAR expressing NK-92 cells, killing Her2+ breast cancer cells (MDA-MB#453).

Shown is the polarisation of lytic granula within the NK cells towards the tumor/NK cell immunological synapse and subsequent killing of target cells (green) turning blue upon apoptosis.

NK cell granula (Lysotracker)  MDA-MB#453 (Cell mask)  Dead cells (Sytox blue)

Enlarged regions:



 

Natalie Wotschel, Jiri Eitler, Torsten Tonn (University of Technology Dresden)